Reproductive Biology Faculty

Jennifer L. Bailit, M.D., M.P.H.
Professor of Reproductive Biology
Department of Obstetrics & Gynecology
Director of Labor and Delivery
Division of Maternal-Fetal Medicine
MetroHealth Medical Center
Center for Health Care Research & Policy Senior Scholar
Women’s Reproductive Health Research Program Scholar
TEL: (216) 778-3550
FAX: (216) 778-8847

Biosketch
Curriculum Vitae

Research Description
Dr. Bailit’s research focuses on how to assess and improve the quality of obstetrical care. Dr. Bailit works with large data sets such as birth certificate data. The overall goal of her research is to improve the quality of obstetrical care.

Selected Publications
Bailit JL for the NICHD MFMU Network. The MFMU Cesarean Registry: Impact of change of shift on Cesarean Complications. American Journal of Obstetrics and Gynecology. 2008;198:2;173.e1-173.e5.

Bailit JL, Love TE. The role of race in cesarean rate case mix adjustment. American Journal of Obstetrics and Gynecology. 2008;198:1; 69.e1-69.e5.

Bailit JL, Votruba ME. Medical cost savings associated with 17 Alpha Hydroxy-progesterone Caproate. American Journal of Obstetrics and Gynecology. 2007, 196:3; 219e1-219e7.

Bailit JL, Love TE, Dawson NV, Quality of obstetric care and risk-adjusted primary cesarean rates. American Journal of Obstetrics and Gynecology. 2006, 194:2;401-407.

Bailit JL, for the NICHD MFMU Network. The MFMU Cesarean Registry: Impact of time of day on Cesarean Complications. American Journal of Obstetrics and Gynecology 2006; 195(4):1132-1137.

Patrick M. Catalano, M.D.
Chairman, Department of Obstetrics & Gynecology
MetroHealth Medical Center
Professor, Department of Reproductive Biology
Case Western Reserve University
Schwartz Center for Metabolism and Nutrition
MetroHealth Medical Center
TEL: (216) 778-4876
FAX: (216) 778-1574

Biosketch
Curriculum Vitae

Research Description
The long range goals of our research are to evaluate metabolic adaptations to pregnancy and the short and long term effects on the mother and fetus. The dramatic increase in the prevalence of obesity worldwide has reached such a degree as to being declared an epidemic level by the WHO. Recent studies have suggested that overgrowth in the fetus is a primary risk factor for developing obesity and associated diseases in children as well as in adults. Our earlier studies have established that maternal pre-gravid obesity and glucose intolerance as observed in gestational diabetes appear to be the strongest risk factors for increased fetal growth. Currently our grant support is focused on evaluating mechanisms by which the maternal metabolic environment affects placental function and nutrient availability for the fetus. In obese women we are evaluating the mechanisms linking the increase in insulin sensitivity and the abnormal expression of adipokines leading to inflammation. Other grants are focused on the ability of nutrient supplements, using a RCT, to decrease inflammation in overweight and obese pregnant women in order to improve insulin sensitivity and subsequently to decrease nutrient availability, particularly lipids, to prevent fetal overgrowth. All of the above studies are currently funded through the National Institutes of Health. Based on our initial results, we hypothesize that the in utero environment is the opportune time to begin the prevention of obesity and subsequent metabolic dysregulation for both the mother and her offspring.

Selected Publications
Landon MB, Spong CY, Thom E, Carpenter MW, Ramin SM, Casey B, Wapner RJ, Varner MW, Rouse DJ, Thorp JM Jr., Sciscione A, Catalano P, Harper M, Saade G, Lain KY, Sorokyn Y, Peaceman AM, Tolosa JE, Anderson GB; A multicenter, randomized trial of treatment for mild gestational diabetes. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. N Engl J Med 2009 Oct 1; 361(14):1339-48.

Catalano PM, Farrell K, Thomas A, Huston-Presley L, Mencin P, de Mouzon SH, Amini SB. Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Ciln Nutr 2009 Nov;90(5):1303-13.

Waters TP, Schultz BA, Mercer BM, Catalano PM. Effect of 17alpha-hydroxyprogesterone caproate on glucose intolerance in pregnancy. Obstet Gynecol 2009 July; 114(1):45-9.

Catalano PM, Presley L, Minium J, Hauguel-de Mouzon S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care 2009 June; 32(6):1076-80.

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: associations with neonatal anthropometrics. HAPO Study Cooperative Research Group. Diabetes 2009 Feb; 58(2):453-9.

Sylvie Hauguel-de Mouzon, Ph.D.
Professor of Reproductive Biology
Director, Molecular Biology Laboratory
OB/GYN
Schwartz Center for Metabolism and Nutriton
MetroHealth Medical Center
TEL: (216) 778-3148
FAX: (216) 778-1574

Biosketch

Research Description
My primary research interest is in the area of mechanisms that regulate the growth of the fetus in utero. Our previous studies have shown that the placenta controls fetal growth by producing hormones and cytokines that regulate fetal energy balance. In pregnancies associated with metabolic dysfunction such as obesity and diabetes the fetus receives too many energy nutrients from maternal circulation and this results in accelerated growth and results in increased fetal adiposity. Our research focuses on the mechanisms which are set up in utero to modify fetal growth. Obesity and diabetes in pregnant women contribute to enhance inflammation at the maternal-fetal interface, with adverse outcomes for placental function (transfer, metabolism and hormone production). Our most recent challenge is to characterize molecular mechanisms which link modifications of maternal metabolic environment and abnormal fetal growth. Analysis of the immunological pathways recruited or developed in both the placenta and maternal adipose tissue is a primary focus of the on-going studies in our group. At a time of nutrient plethora in the population of pregnant women another major direction of our research is to determine the interaction between sugar and lipids as energy substrates for accretion of adipose tissue during fetal development. Our studies have important implications as they relate to our understanding of the fetal origin of adult diseases and ultimately its prevention.

Selected Publications
Radaelli T, Lepercq J, Varastehpour A, Basu S, Catalano PM, Hauguel-de Mouzon S. Differential regulation of genes for feto-placental lipid pathways in pregnancy with gestational and type 1 diabetes. Am JOG (2009) 201:e201-209.

Catalano PM, Presley L, Minium J, Hauguel-de Mouzon S. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care (2009) 32:1076-1080.

Pinar H, Basu S, Hotmire K, Laffineuse L, Presley L, Carpenter M, Catalano PM, Hauguel-de Mouzon S. High molecular weight multimer complexes and vascular expression contribute to high adiponectin in the fetus. J Clin Endocrinol Metab (2008) 93:2885-90.

Challier JC, Bintein T, Basu S, Hotmire K, Minium J, Catalano PM, Hauguel-de Mouzon S. Obesity in Pregnancy stimulates macrophage accumulation and inflammation in the placenta. Placenta (2008) 29(3):274-81.

Lepercq J, Catalano P, Hauguel de Mouzon S. Leptin in pregnancy: facts, questions and future. Gynecol Obstet Fertil (2007) 35(2):89-95.

Brian M. Mercer, M.D.
Professor of Reproductive Biology
Case Western Reserve University
Director, Obstetrics & Maternal-Fetal Medicine
MetroHealth Medical Center
TEL: (216) 778-8446
FAX: (216) 778-8847


Biosketch

Research Description
Dr. Mercer conducts research related to clinical complications of pregnancy, with a focus on prediction and prevention of preterm birth and its complications. He has extensive experience in the conduct and analysis of clinical studies and multicenter randomized trials related to prematurity prevention. These studies involve women with prior obstetric complications and also those at risk for preterm birth in the current pregnancy.

Selected Publications
Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Alexander JM, Harper M, Thorp JM Jr, Ramin SM, Malone FD, Carpenter M, Miodovnik M, Moawad A, O`Sullivan MJ, Peaceman AM, Hankins GD, Langer O, Caritis SN, Roberts JM; Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network. A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med 2008;359:895-905.

Mercer BM, Merlino AA, Milluzzi CJ, Moore JJ. Small fetal size before 20 weeks` gestation: associations with maternal tobacco use, early preterm birth, and low birthweight. Am J Ob Gyn 2008;198:673-5.

Mercer BM, Gilbert S, Landon MB, Spong CY, Leveno KJ, Rouse DJ, Varner MW, Moawad AH, Simhan HN, Harper M, Wapner RJ, Sorokin Y, Miodovnik M, Carpenter M, Peaceman A, O`Sullivan MJ, Sibai BM, Langer O, Thorp JM, Ramin SM; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Labor outcomes with increasing number of prior vaginal births after cesarean delivery. Obstet Gynecol 2008;111:285-91.

Wapner RJ, Sorokin Y, Mele L, Johnson F, Dudley DJ, Spong CY, Peaceman AM, Leveno KJ, Malone F, Caritis SN, Mercer B, Harper M, Rouse DJ, Thorp JM, Ramin S, Carpenter MW, Gabbe SG; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Long-term outcomes after repeat doses of antenatal corticosteroids. N Engl J Med 2007;357:1190-8.

Rouse DJ, Caritis SN, Peaceman AM, Sciscione A, Thom EA, Spong CY, Varner M, Malone F, Iams JD, Mercer BM, Thorp J, Sorokin Y, Carpenter M, Lo J, Ramin S, Harper M, Anderson G; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. N Engl J Med. 2007;357:454-61.

John J. Moore, M.D.
Professor of Pediatrics and Reproductive Biology
Case Western Reserve University
Director, Division of Neonatology
MetroHealth Medical Center
Program Director, CWRU-CCF-MetroHealth Neonatology Fellowship Training Program
TEL: (216) 778-5909, (216) 778-5946
FAX: (216) 778-3252


Web Site

Research Description
The general area of my research interest is the determination of the control system for the onset of human parturition. This problem in physiology has direct clinical importance because premature and dysfunctional labors result in significant neonatal mortality and morbidity. Early rupture of the fetal membranes results in approximately one third of preterm births. Our research focus is the determination of the mechanisms of the developmental process of fetal membrane weakening, leading to rupture. This weakening appears to be a tissue remodeling process involving apoptosis and activation of matrix metalloproteinases. We have developed technology to measure the physical strength properties of fetal membranes (in vitro) and to correlate these with biochemical and histological characteristics. This has allowed us to determine, for the first time, that a zone of weakness with unique biochemical and histological characteristics develops in the membrane region overlying the cervix in late gestation. We are exploring the gestational timing of this event, its physiological control, and the potential to therapeutically reverse this process. Our hope is to be able to provide some therapeutic help for the 40% of preterm births in which the initiating event is preterm rupture of the fetal membranes.

Selected Publications
Moore RM, Redline RW, Kumar D, Mercer BM, Mansour JM, Yohannes E, Novak JB, Chance MR, Moore JJ. Differential expression of fibulin family proteins in the para-cervical weak zone and other areas of human fetal membranes. Placenta 30: 335341, 2009.

Moore RM, Novak JB, Kumar D, Mansour JM, Mercer BM, Moore JJ. Alpha-lipoic acid inhibits Tumor Necrosis Factor-induced remodeling and weakening of human fetal membranes. Biol Reprod 80: 781787, 2009. Published online before print 23 December 2008. DOI 10.1095/biolreprod.108.073205rint].

Pandey V, Jaremko K, Moore RM, Mercer B, Stetzer B, Kumar D, Fox J, Mansour J, Moore JJ. The force required to rupture fetal membranes paradoxically increases with acute in vitro repeated stretching. Am J OB Gynecol 196:165.e1-165.e7, 2007.

Moore RM, Mansour JM, Redline R, Mercer BM, Moore JM. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta 27:1037-1051, 2006.

Kumar D, Fung W, Moore RM, Pandey V, Fox J, Stetzer B, Mansour JM, Mercer BM, Redline RW, Moore JJ. Inflammatory mediators found in amniotic fluid induce collagen remodeling, apoptosis, and biophysical weakening of cultured fetal membranes. Biol Reprod 74:29-34, 2006.

Peter R. Rose, M.D.
Professor of Reproductive Biology and Oncology
Director of Gynecologic Oncology
TEL: (216) 778-5695
FAX: (216) 778-4741


Curriculum Vitae

Research Description
Dr. Rose`s clinical activity involves the care of women with Gynecologic Cancer. In an effort to improve patient outcome and provide the most recent and promising treatments Dr. Rose is involved in numerous National Cancer Institute, Gynecologic Oncology Group, and industry sponsored trials.

Selected Publications
ROSE PG. Fallopian tube cancer. In: Textbook of Uncommon Cancer, Second Ed. Raghavan D, Brecher ML, Johnson DH, Meropol NJ, Moots PL, Thigpen JT (eds), John Wiley & Sons, Ltd., Sussex England 1999, pp 689-700.

ROSE PG. Uterine Sarcoma. In: Textbook of Uncommon Cancer, Second Ed. Raghavan D, Brecher ML, Johnson DH, Meropol NJ, Moots PL, Thigpen JT (eds), John Wiley & Sons, Ltd., Sussex, England 1999, pp 689-700.

ROSE PG, Blessing JA, Gershenson DM, McGhee R. Paclitaxel and cisplatin as first line therapy in recurrent or advanced squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study. J Clin Oncol 17:2676-2680, 1999.